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Brandon Aiyuk is one of the must-start wide receivers in Week 6 fantasy football.

My must-start wide receivers for Week 6 of the 2022 fantasy football season are Brandon Aiyuk and DeVonta Smith.

Each of my must-start pass catchers is ranked among the top 42 in my rankings, indicating that they should be in lineups for leagues with at least 14 teams and the ability to start up to three wide receivers.

Justin Jefferson of the Minnesota Vikings leads my overall Top 50 wide receiver rankings for Week 4. Stefon Diggs, Cooper Kupp, Ja’Marr Chase, and A.J. Brown are all among my top five players.

Chris Godwin, Tyreek Hill, DK Metcalf, Gabriel Davis and DeVonta Smith are among my Top 10 options and should be in every starting lineup.

Davante Adams, Amon-Ra St. Brown and Brandin Cooks are among the wide receivers who should be out of fantasy football lineups as the Las Vegas Raiders, Detroit Lions, Houston Texans and Tennessee Titans will each serve Week 6 byes.

Gabriel Davis

Davis logged 88 yards and a score in Week 1, but struggled in his next two appearances this season. He rebounded with 171 yards and two scores on three catches in the Buffalo Bills’ Week 5 win over the Pittsburgh Steelers.

The Bills offense ranks No. 1 in the NFL overall, led by quarterback Josh Allen’s top-ranked passing attack. This week, they will battle the Kansas City Chiefs in what is expected to be a shootout.

The Chiefs allowed the eighth-most fantasy points and tied for allowing the third-most receiving scores to wide receivers through five games. I expect Allen and Chiefs quarterback Patrick Mahomes to throw for more than 300 yards apiece in this meeting of AFC powers.

That prolific passing duel should lead all of their pass catches to fantasy football relevance. Davis should find the end zone again. I also expect at least eight targets for the Bills weapon.

He is my No. 9 option for Week 6.