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Microbiota, obesity, and asthma immunological interactions

Common inflammatory illnesses that are mediated by distinct immunological characteristics include asthma and obesity. Asthma, for instance, is connected to the Th2 response, but obesity is connected to the Th1/Th17 profile.

More severe asthmatic reactions happen more frequently when these immunological traits are combined. Lately, it has been discovered that changes in an individual’s microbiome are related to changes in immunological characteristics in relation to obesity and asthma.

An allergen that may cause childhood asthma has been identified, according to a recent Immunology Letters study. This study also highlights the pathways that lead to asthma that is made worse by obesity, and it shows how maternal obesity affects the development of the offspring’s gut and lungs’ microbiota, which causes asthma.Asthma is a long-term inflammatory condition of the lungs that frequently results in episodes of airway hyperresponsiveness (AHR). Wheezing, coughing, chest tightness, and shortness are a few of the symptoms this illness frequently causes.

Progressive lung function loss brought on by chronic inflammation has the potential to be fatal. One recent study found that asthma affects 18% of people worldwide.

The most prevalent type of asthma is atopic asthma, which is predisposed genetically to produce a lot of immunoglobulin E (IgE) that is specific to an antigen in reaction to allergens. Vulnerable individuals release alarmins such Thymic Stromal Lymphoietin (TSLP), interleukin 25 (IL-25), and IL-33 when exposed to allergens. These alarmins then cause basophils, innate lymphoid cells (ILC)2, dendritic cells (DCs), and mast cells.